3160-91-6 → 3731-59-7

HRID 372192Notes

Reaction equation

HRID 372192 reaction equation
[CH2:1]1[N:6]([C:7]([N:9]=[C:10]([NH2:12])[NH2:11])=[NH:8])[CH2:5][CH2:4][O:3][CH2:2]1.Cl.[C:14]([OH:21])(=[O:20])/[CH:15]=[CH:16]\[C:17]([OH:19])=[O:18]>O>[CH2:5]1[N:6](/[C:7](/[NH2:8])=[N:9]/[C:10]([NH2:12])=[NH:11])[CH2:1][CH2:2][O:3][CH2:4]1.[CH2:5]1[N:6](/[C:7](/[NH2:8])=[N:9]/[C:10]([NH2:12])=[NH:11])[CH2:1][CH2:2][O:3][CH2:4]1.[C:14]([O-:21])(=[O:20])/[CH:15]=[CH:16]\[C:17]([O-:19])=[O:18]

Participants

5

Reactant 2

HCID 766213160-91-6HCID 444266Maleic Acid

Product 2

HCID 1373459673731-59-7HCID 178513034HCID 178513034, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Alternatively, the free base of moroxydine is prepared, e.g.: 2.1 g. moroxydine hydrochloride is dissolved in 100 ml. water and treated with an anion exchange resin. The resulting solution is neutralized, for example, with maleic acid and evaporated to crystallization yielding moroxydine maleate.

Workup

  1. customevaporated to crystallization

Sources & evidence

ORD record
ord-cdf05f39d8c5430eae2c8181c52744c2
Source dataset
uspto-grants-1978_05
Patent number
US04089957

Reaction notes

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