Ammonia → HCID 20328011, compound

HRID 372193Notes

Reaction equation

HRID 372193 reaction equation
[Br:1][C:2]1[C:6]([Br:7])=[C:5]([Br:8])[N:4]([CH2:9][C:10]([O:12]CC)=O)[N:3]=1.[NH3:15]>C(O)C>[Br:1][C:2]1[C:6]([Br:7])=[C:5]([Br:8])[N:4]([CH2:9][C:10]([NH2:15])=[O:12])[N:3]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20327983Ethyl (3,4,5-tribromo-1H-pyrazol-1-yl)acetate

Product 1

HCID 20328011HCID 20328011, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution consisting of 9.7 gm. (0.025 mole) ethyl 3,4,5-tribromopyrazole-1-acetate in 250 ml. ethanol was saturated with gaseous ammonia and held at about 25° C. for 3 days. After removing most of the ethanol by evaporation under reduced pressure, the solids that formed were collected on a filter and recrystallized from a mixture of ethanol and water. There was thus obtained 5.8 gm. of 3,4,5-tribromopyrazole-1-acetamide having a melting point at 234° to 236° C.

Workup

  1. customAfter removing most of the ethanol by evaporation under reduced pressure
  2. customthe solids that formed
  3. customwere collected on
  4. filtrationa filter
  5. customrecrystallized from a mixture of ethanol and water
  6. customat 234° to 236° C.

Sources & evidence

ORD record
ord-318b3c4d4d53480ea0a596ce49bfecd4
Source dataset
uspto-grants-1978_05
Patent number
US04089672

Reaction notes

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