HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-[4-(2-Butyl-4-chloro-5-formyl-imidazol-1-yl-methyl)-phenyl]-2-cyclopentylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 2-[4-(2-butyl-4-chloro-5-formyl-imidazol-1-yl-methyl)phenyl]-2-cyclopentylacetate | HCID 15225591 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-[4-(2-Butyl-4-chloro-5-formyl-imidazol-1-yl-methyl)-phenyl]-2-cyclopentylacetic acid | HCID 15225590 | — |
Reaction Steps
2.3 g (5 mmol) of the compound of Example IV are stirred in 5 ml of dichloromethane and 5 ml of trifluoroacetic acid for 5 hours at 25° C. After concentration, the crude product is chromatographed over silica gel 60 using dichloromethane/methanol (100:5). Yield: 1.8 g (87.6% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05420149 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-68dd6011683e427fae106bee09903191 |
| Source note | uspto-grants-1995_05 |