2-Aminomethyl-1-ethylpyrrolidine → Benzyl Alcohol

Participants

Reaction Steps

6.7 g (0.04 mole) of methyl 4-methoxynicotinate (m.p. 82°-83° C, W. C. J. Ross, J. Chem. Soc. 1966, 1816) and 7.18 g (0.06 mole) of 1-ethyl-2-(aminomethyl)-pyrrolidine are dissolved in 50 ml of xylene and the solution is heated for 6 hours so that a slow distillation takes place. Approx. 15 ml of distillate with a boiling point of 60°-80° C are collected. The mixture is then completely concentrated in a high vacuum at 50°-60° C and the oily residue obtained is chromatographed through a column of 200 g of basic silica gel. Pure N-[(1-ethyl-2-pyrrolidinyl)-methyl]-4-methoxynicotinamide is obtained as an oil with benzene-methanol (99:1) as eluant.

Provenance & Evidence