反应详情

To a solution of 3-(dimethylamino)-1-decyn-5-one (2.2 g) described in Example 39, in methanol (20 ml) p-toluenesulfonic acid (1 g) is added. The solution is allowed to stay at room temperature for 5 hr. then diluted with ether. The organic layer is washed with water, dried (MgSO4) and evaporated to dryness. Chromatographic purification of the residue on 25 g silica gel with ether-hexane (1:4) affords 3-decen-1-yn-5-one.

1. additionis added
2. washThe organic layer is washed with water
3. dry with materialdried (MgSO4)
4. customevaporated to dryness
5. customChromatographic purification of the residue on 25 g silica gel with ether-hexane (1:4)