Sodium Hydroxide → HCID 23718181, compound

HRID 372231Notes

Reaction equation

HRID 372231 reaction equation
[C:1]1([CH3:20])[CH:6]=[CH:5][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([OH:19])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+:22]>CO>[C:1]1([CH3:20])[CH:2]=[CH:3][C:4]([C:7]([C:9]2[N:13]3[CH2:14][CH2:15][CH:16]([C:17]([O-:19])=[O:18])[C:12]3=[CH:11][CH:10]=2)=[O:8])=[CH:5][CH:6]=1.[Na+:22]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13487034HCID 13487034, compound

Product 1

HCID 23718181HCID 23718181, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 300 mg. of 5-p-toluoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid in 5 ml. of methanol is added 1 molar equivalent of sodium hydroxide, in the form of a 0.1N solution. The solvent is then evaporated under reduced pressure and the residue taken up in 2 ml. of methanol, followed by precipitation with ether, to yield crude sodium 5-p-toluoyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate which can be crystallized from ethyl acetate-hexane.

Workup

  1. customThe solvent is then evaporated under reduced pressure
  2. customof methanol, followed by precipitation with ether

Sources & evidence

ORD record
ord-3a7153f99f774caa97aa9c96719f7826
Source dataset
uspto-grants-1978_05
Patent number
US04089969

Reaction notes

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