反应详情

A solution of 14 g. (0.11 mole) of 3-hydroxyquinolizidine in 75 ml. of thionyl chloride and 50 ml. of benzene was refluxed for one hour. The solvent was completely evaporated, and the residue dissolved in chloroform. The solution was passed through an alumina column and evaporation of the chloroform gave crude 3-chloroquinolizidine. The crude material was chromatographed on an alumina column eluting with ether-petroleum ether, 1:19 to yield pure 3-chloroquinolizidine.

1. customThe solvent was completely evaporated
2. dissolutionthe residue dissolved in chloroform
3. customThe solution was passed through an alumina column and evaporation of the chloroform
4. customgave crude 3-chloroquinolizidine
5. customThe crude material was chromatographed on an alumina column
6. washeluting with ether-petroleum ether, 1:19