反应详情

A mixture of 6.9 g. of cis and trans-N-(1,2,3,4-tetrahydro-4-methoxy-1-naphthyl)acetamide, 56.11 g. of potassium hydroxide, 50 ml. of ethylene glycol and 20 ml. of water is stirred and heated at reflux for an overnight period. The mixture is cooled, 100 ml. of water is added and the mixture extracted with methylene chloride (3 × 50 ml.). The combined extract was washed with 125 ml. of 10% sodium hydroxide solution, dried and evaporated in vacuo to afford 5.7 g. of title product - an oil. This oily amine is used without further purification for the preparation of the urea derivative.

1. additionA mixture of 6.9 g
2. temperatureheated
3. temperatureat reflux for an overnight period
4. temperatureThe mixture is cooled
5. extractionthe mixture extracted with methylene chloride (3 × 50 ml.)
6. extractionThe combined extract
7. washwas washed with 125 ml
8. dry with materialof 10% sodium hydroxide solution, dried
9. customevaporated in vacuo
10. customto afford 5.7 g
11. customThis oily amine is used without further purification for the preparation of the urea derivative