HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → {[2-Hydroxy-4-methoxy-alpha-(4-chlorophenyl)benzyliden]amino}malonic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Propanedioic acid, 2-amino-, 1,3-diethyl ester, hydrochloride (1:1) | HCID 3084143 | — |
| Reactant | 4'-Chloro-2-hydroxy-4-methoxy-benzophenone imine | HCID 136388410 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | {[2-Hydroxy-4-methoxy-alpha-(4-chlorophenyl)benzyliden]amino}malonic acid diethyl ester | HCID 136388411 | — |
Reaction Steps
10.5 G. of 4'-chloro-2-hydroxy-4-methoxy-benzophenone imine in 60 ml. of ethanol is reacted with 12.6 g. of aminomalonic acid diethyl ester hydrochloride and 5.0 ml. of pyridine in accordance with the procedure described in Example 2. After a single recrystallization of the crude product from ethanol, there is obtained {[2-hydroxy-4-methoxy-α-(4-chlorophenyl)benzyliden]amino}malonic acid diethyl ester, having a melting point of 73°-75° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04089875 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-a90c9380062d4833b452acf2b84fb182 |
| Source note | uspto-grants-1978_05 |