反应详情

A mixture of 2-methyleneglutaric acid [Ber. 34, 427 (1901)] (40 g.) and acetyl chloride (80 ml.) is heated on the steam bath for 1.5 hours. The excess acetyl chloride is removed in vacuo (75°) and the residue is evaporated from toluene twice. Finally, the residue is dissolved in ethanol and heated on the steam bath for 1 hour. The reaction mixture is concentrated to dryness to yield 2-methylene-4-(ethoxycarbonyl)butyric acid.

1. temperatureis heated on the steam bath for 1.5 hours
2. customThe excess acetyl chloride is removed in vacuo (75°)
3. customthe residue is evaporated from toluene twice
4. dissolutionFinally, the residue is dissolved in ethanol
5. temperatureheated on the steam bath for 1 hour
6. concentrationThe reaction mixture is concentrated to dryness