Methyl Isocyanate → 1-Methyl-3-(1,2,3,4-tetrahydro-4-hydroxy-1-naphthyl)urea

HRID 372402Notes

Reaction equation

[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH2:12])[CH2:4][CH2:3]1.[CH3:13][N:14]=[C:15]=[O:16]>>[CH3:13][NH:14][C:15]([NH:12][CH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:2]([OH:1])[CH2:3][CH2:4]1)=[O:16]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 203273134-Amino-1,2,3,4-tetrahydronaphthalen-1-ol

Product 1

HCID 203273191-Methyl-3-(1,2,3,4-tetrahydro-4-hydroxy-1-naphthyl)urea

Procedure

Similarly, 1,2,3,4-tetrahydro-4-hydroxy-1-naphthylamine is allowed to react with an equivalent amount of methyl isocyanate to afford 1-methyl-3-(1,2,3,4-tetrahydro-4-hydroxy-1-naphthyl)urea, m.p. 172° C. to 180° C.

Sources & evidence

ORD record: ord-74521b12c1b84c9b9107b2392c90c3df
Source dataset: uspto-grants-1978_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04091018

Reaction notes

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