p-Toluenesulfonic acid monohydrate → HCID 86735718, compound

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Reaction Steps

To a magnetically stirred solution of 31.4 g. (0.0534 mole) of benzyl 6'-tritylamino-spiro[cyclohexane-1,2'-penam]-3'-carboxylate in 300 ml. of anhydrous acetone, there is added a solution of 10.2 g. (0.0535 mole) of p-toluene-sulfonic acid monohydrate in 300 ml. of anhydrous acetone. After stirring for 2.5 hours at ambient temperature, a precipitate is obtained which is removed by filtration, washed with acetone and then with diethyl ether and dried. 10.1 g. of benzyl 6'-amino-spiro[cyclohexane-1,2'-penam]-3'-carboxylate p-toluenesulfonate are obtained. Yield: 36.5%.

Provenance & Evidence