Sodium borohydride → HCID 22767870, compound

HRID 372443Notes

Reaction equation

HRID 372443 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH:11]=[C:10]([N:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)[C:9]3[CH:19]=[CH:20][C:21]([C:23]([F:26])([F:25])[F:24])=[CH:22][C:8]=3[O:7][C:6]=2[CH:27]=1.[BH4-].[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH:10]([N:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)[C:9]3[CH:19]=[CH:20][C:21]([C:23]([F:26])([F:25])[F:24])=[CH:22][C:8]=3[O:7][C:6]=2[CH:27]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 22767875HCID 22767875, compound

Product 1

HCID 22767870HCID 22767870, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

11.9 G. of 1-[3-chloro-7-trifluoromethyl-dibenz[b,f]oxepin-10-yl]-4-methyl-piperazine was reduced with sodium borohydride in glacial acetic acid in a manner analogous to that described in Example 14, and there is obtained crude 1-[3-chloro-10,11-dihydro-7-trifluoromethyl-dibenz[b,f]oxepin-10-yl]-4-methyl-piperazine which is recrystallized from isopropanol and melts at 110° C. The dihydrochloride, prepared in ethanol, melts at 219°-222° C. (with decomposition).

Sources & evidence

ORD record
ord-ee4d466ef3514a1ebf6bd81761b55f80
Source dataset
uspto-grants-1978_05
Patent number
US04091023

Reaction notes

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