Azobisisobutyronitrile → 3-(dimethylphosphinyl)-propyl N-(7-chloro-4-quinolyl)-anthranilate

Participants

Reaction Steps

A mixture of 3.37 grams (0.01 mol) of allyl 7-chloro-4-quinolyl-anthranilate (melting point 112° C) dissolved in 60 ml of toluene and 1.17 grams (0.015 mol) of dimethylphosphine oxide is heated to 100° C. 30 mg of α,α'-azo-bis-isobutyronitrile in 10 ml of toluene are then added dropwise to catalyse the addition of the dimethylphosphine oxide to the allyl double bond. From the cooled solution, 3-(dimethylphosphinyl)-propyl N-(7-chloro-4-quinolyl)-anthranilate is isolated; melting point 162° C (after recrystallisation from acetone); yield: 3.58 grams (86% of theory).

Provenance & Evidence