Sodium borohydride → HCID 54298099, compound

Participants

Reaction Conditions

Reaction Steps

8.8 g of sodium borohydride were added over 20 minutes at 22°-26° C to a solution of 8.8 g of the product of Step A in 8.8 ml of ethanol and 8.8 ml of water and the mixture was stirred for 1 hour at 20° C. The ethanol was evaporated and the mixture was poured into water and was extracted with methylene chloride. The organic extracts were washed with water, dried and evaporated to dryness to obtain 9 g of a mixture of the isomers of raw 7-(4-methylpiperazin-1-yl)-5-hydroxy-6,7,8,9-tetrahydro [5H] benzocycloheptene which was used as is for the next step.

Provenance & Evidence