Sulfuric Acid → HCID 21152206, compound

Participants

Reaction Conditions

Reaction Steps

18 ml of 18 N sulfuric acid were added to a refluxing solution of 9 g of the product of Step B in 180 ml of dioxane and the mixture was refluxed for 30 minutes and then was concentrated and cooled to 20° C. 100 ml of ice-water were added thereto and the mixture was extracted with ethyl acetate. The aqueous phase was made alkaline with concentrated ammonium hydroxide and was extracted with methylene chloride. The organic phase was dried and evaporated to dryness to obtain 6.2 g of 7-(4-methylpiperazin-1-yl)-6,7-dihydro [5H] benzocycloheptene.

Provenance & Evidence