3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 20326282, compound

Participants

Reaction Steps

A solution of the sodium salt of antibiotic X-537A (6.12 g.) in pyridine (10 ml.) was stirred at room temperature under nitrogen with 3 g. of nicotinoyl chloride hydrochloride for 13 days. Extraction and purification as in Example 22 gave a yellow residue which resisted crystallization. Attempted crystallization from hexane gave a gum which was dried on a clay plate to an amorphous solid, m.p. 81°-92° (dec.) [α]D25 -14.64° (C=1.04 in methanol).

Provenance & Evidence