反应详情

A stirred solution of 6.3 grams of 2,4,6-trichloro-5-pyrimidinecarbonitrile in 25 ml of acetone was cooled to -10°, and 2.5 grams of 2-amino-2-methylpropionitrile was added. With the reaction mixture at -10°, a solution of 1.3 grams of sodium hydroxide in 3.5 ml of water was added dropwise. Upon complete addition, the reaction mixture was stirred at -10° for 30 minutes. The acetone was removed under reduced pressure; the residue was extracted with diethyl ether, and the extract was separated and dried over magnesium sulfate. The extract was filtered, and the filtrate was evaporated under reduced pressure, yielding a residue. The residue was recrystallized from methylcyclohexane to give 3.1 grams of 4,6-dichloro-2-(1-cyano-1-methylethylamino)-5-pyrimidinecarbonitrile; mp, 154-158°.

1. additionUpon complete addition
2. customThe acetone was removed under reduced pressure
3. extractionthe residue was extracted with diethyl ether
4. customthe extract was separated
5. dry with materialdried over magnesium sulfate
6. filtrationThe extract was filtered
7. customthe filtrate was evaporated under reduced pressure
8. customyielding a residue
9. customThe residue was recrystallized from methylcyclohexane