反应详情

A stirred solution of 4.2 grams of 2,4,6-trichloro-5-pyrimidinecarbonitrile in 100 ml of diethyl ether was cooled to between -5° and -10°, and a solution of 2.4 grams of isopropylamine in 100 ml of diethyl ether was added dropwise. Upon complete addition, water was added to the reaction mixture, and the ether layer was separated. The ethereal layer was dried over magnesium sulfate and filtered. The filtrate was evaporated to dryness under reduced pressure. The residue was recrystallized from methylcyclohexane to give 2.4 grams of 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile; mp, 179°-181°.

1. additionwas added to the reaction mixture
2. customthe ether layer was separated
3. dry with materialThe ethereal layer was dried over magnesium sulfate
4. filtrationfiltered
5. customThe filtrate was evaporated to dryness under reduced pressure
6. customThe residue was recrystallized from methylcyclohexane