Isopropylamine → 4-Chloro-2-(1-cyano-1-methylpropylamino)-6-cyclopropylamino-5-pyrimidinecarbonitrile

HRID 372648Notes

Reaction equation

HRID 372648 reaction equation
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.Cl[C:6]1[C:11]([C:12]#[N:13])=[C:10]([Cl:14])[N:9]=[C:8]([NH:15][C:16]([C:19]#[N:20])([CH3:18])[CH3:17])[N:7]=1.[CH:21](N)(C)C>>[Cl:14][C:10]1[C:11]([C:12]#[N:13])=[C:6]([NH:4][CH:1]2[CH2:3][CH2:2]2)[N:7]=[C:8]([NH:15][C:16]([C:19]#[N:20])([CH3:18])[CH2:17][CH3:21])[N:9]=1

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 69828CyclopropylamineHCID 537123174,6-Dichloro-2-(1-cyano-1-methylethylamino)-5-pyrimidinecarbonitrile

Product 1

HCID 537277614-Chloro-2-(1-cyano-1-methylpropylamino)-6-cyclopropylamino-5-pyrimidinecarbonitrile

Procedure

This compound was prepared in the manner of Example X, substituting 4,6-dichloro-2-(1-cyano-1-methylpropylamino)-5-pyrimidinecarbonitrile and cyclopropylamine for 4, 6-dichloro-2-(1-cyano-1-methylethylamino)-5-pyrimidinecarbonitrile and isopropylamine. The reaction product was recrystallized from carbon tetrachloride to give 4-chloro-2-(1-cyano-1-methylpropylamino)-6-cyclopropylamino-5-pyrimidinecarbonitrile; mp, 155°-159°.

Workup

  1. customThis compound was prepared in the manner of Example X
  2. customThe reaction product was recrystallized from carbon tetrachloride

Sources & evidence

ORD record
ord-88698535bb824b5f913a5264401f5442
Source dataset
uspto-grants-1978_05
Patent number
US04092150

Reaction notes

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