HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 4-Chloro-6-cyclopropylamino-2-isopropylamino-5-pyrimidinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 4,6-Dichloro-2-ethylamino-5-pyrimidinecarbonitrile | HCID 20510256 | — |
| Product | 4-Chloro-6-cyclopropylamino-2-isopropylamino-5-pyrimidinecarbonitrile | HCID 20510267 | — |
Reaction Steps
This compound was prepared in the manner of Example XVII, substituting 4,6-dichloro-2-isopropylamino-5-pyrimidinecarbonitrile and cyclopropylamine for 4,6-dichloro-2-ethylamino-5-pyrimidinecarbonitrile and isopropylamine, producing 4-chloro-6-cyclopropylamino-2-isopropylamino-5-pyrimidinecarbonitrile. Upon recrystallization from methylcyclohexane, the melting point was 157°-160°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04092150 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-7fbe24f0a8654fd9ab27be8b7d876e6f |
| Source note | uspto-grants-1978_05 |