HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-Ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 4-Chloro-2-(1-cyano-1-methylethylamino)-6-ethylamino-5-pyrimidinecarbonitrile | HCID 53816645 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile | HCID 20510200 | — |
Reaction Steps
This compound was prepared in the manner of Example XXXIII, substituting 4-chloro-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile and a solution of sodium in ethanol for 4-chloro-2-(1-cyano-1-methylethylamino)-6-ethylamino-5-pyrimidinecarbonitrile and a solution of sodium in methanol. The reaction product was recrystallized from petroleum ether to give 4-ethoxy-6-ethylamino-2-isopropylamino-5-pyrimidinecarbonitrile; mp, 98°-99°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04092150 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-145fe1dce161482889350fbb0c6124f6 |
| Source note | uspto-grants-1978_05 |