Sodium Methoxide → 6-Cyclopropylamino-2-isopropylamino-4-methoxy-5-pyrimidinecarbonitrile

Participants

Reaction Steps

To a stirred solution of 0.9 gram of sodium methoxide in 100 ml of methanol was added, in one portion, 4.0 grams of 4-chloro-6-cyclopropylamino-2-isopropylamino-5-pyrimidinecarbonitrile. The reaction mixture was then heated under reflux for 3 hours. The methanol was removed by evaporation under reduced pressure to give a residue. The residue was washed with water, and the solid was collected by filtration to yield 3.5 grams of 6-cyclopropylamino-2-isopropylamino-4-methoxy-5-pyrimidinecarbonitrile; mp, 142°-147°.

Provenance & Evidence