Thionyl Chloride → HCID 20326456, compound

HRID 372667Notes

Reaction equation

HRID 372667 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][C:9](=[O:16])[C:10](=[CH:14][CH:15]=2)[C:11](O)=O)=[CH:3][CH:2]=1.S(Cl)([Cl:19])=O>CCCCCC>[ClH:19].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[NH:8][C:9](=[O:16])[C:10](=[CH:14][CH:15]=2)[CH2:11][Cl:19])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 203264526-Oxo-1,6-dihydro[2,4'-bipyridine]-5-carboxylic acid

Product 1

HCID 20326456HCID 20326456, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A mixture of 13 g. of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinic acid (U.S. Pat. No. 3,873,523) and 90 ml. of thionyl chloride is stirred at room temperature for 16 hours, then diluted with 250 ml. of hexane. The resulting precipitate of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is collected by filtration, washed with hexane and dried.

Workup

  1. additionA mixture of 13 g
  2. additiondiluted with 250 ml
  3. filtrationThe resulting precipitate of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinyl chloride hydrochloride is collected by filtration
  4. washwashed with hexane
  5. customdried

Sources & evidence

ORD record
ord-9e901e3f04f341e989b448ffc6cd75c1
Source dataset
uspto-grants-1978_05
Patent number
US04092309

Reaction notes

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