Benzyl Alcohol → HCID 12899210, compound

Participants

Reaction Steps

A 5.8 g quantity of metal sodium is dissolved in a mixture of 100 ml of benzyl alcohol and 200 ml of toluene, 16.7 g of 2,4-dichloro-5-fluoropyrimidine is added to the solution, and the mixture is refluxed for 4 hours. The resulting reaction mixture is washed with water, dried and distilled at reduced pressure to give 27.0 g of colorless oily 2,4-di(benzyloxy)-5-fluoropyrimidine in a yield of 87.1%, b.p. 205°-206° C/3-4 mm Hg and m.p. 48.5°-49.5° C.

Provenance & Evidence