Prazosin Hydrochloride → Prazosin

HRID 372680Notes

Reaction equation

HRID 372680 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14]([NH2:15])=[N:13][C:12]([N:16]3[CH2:21][CH2:20][N:19]([C:22]([C:24]4[O:28][CH:27]=[CH:26][CH:25]=4)=[O:23])[CH2:18][CH2:17]3)=[N:11][C:6]2=[CH:7][C:8]=1[O:9][CH3:10].Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:14]([NH2:15])=[N:13][C:12]([N:16]3[CH2:21][CH2:20][N:19]([C:22]([C:24]4[O:28][CH:27]=[CH:26][CH:25]=4)=[O:23])[CH2:18][CH2:17]3)=[N:11][C:6]2=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 1

HCID 68546Prazosin Hydrochloride2×

Product 1

HCID 4893Prazosin

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
95 °C

Procedure

To 500 ml. of water, 50 g. of the α-form of prazosin hydrochloride was added and the mixture stirred and heated to 95° C. for 2 hours. After cooling to about 50° C. the slurry was filtered, washed with water and dried in air for 48 hours to obtain 50.5 g. of prazosin hydrochloride polyhydrate containing 12.4% water. The infrared spectrum obtained with a KBr disc was identical to that shown in FIG. II.

Workup

  1. temperatureAfter cooling to about 50° C. the slurry
  2. filtrationwas filtered
  3. washwashed with water
  4. customdried in air for 48 hours
  5. customto obtain 50.5 g

Sources & evidence

ORD record
ord-2f64e0e9ecb84bc496ad00a1f9a029b0
Source dataset
uspto-grants-1978_05
Patent number
US04092315

Reaction notes

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