反应详情

温度

95 °C

To 500 ml. of water, 50 g. of the α-form of prazosin hydrochloride was added and the mixture stirred and heated to 95° C. for 2 hours. After cooling to about 50° C. the slurry was filtered, washed with water and dried in air for 48 hours to obtain 50.5 g. of prazosin hydrochloride polyhydrate containing 12.4% water. The infrared spectrum obtained with a KBr disc was identical to that shown in FIG. II.

1. temperatureAfter cooling to about 50° C. the slurry
2. filtrationwas filtered
3. washwashed with water
4. customdried in air for 48 hours
5. customto obtain 50.5 g