HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → 1,5-Naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | 3-Aminopyridine | HCID 10009 | — |
| Reactant | 1,5-Naphthyridine | HCID 136070 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,5-Naphthyridine | HCID 136070 | — |
| Product | 1,2,3,4-Tetrahydro-1,5-naphthyridine | HCID 6917495 | — |
Reaction Steps
1,5-Naphthyridine was prepared from 3-aminopyridine according to the method described in J. Org. Chem., 1963, 1757 and was isolated as colourless needles from n-hexane m.p. 69° C (lit. 74°). 1,5-Naphthyridine (2.6 g.) was hydrogenated in 95% ethanol over PtO2 catalyst under atmospheric conditions to give 1,2,3,4-tetrahydro-1,5-naphthyridine as colourless needles (2.51 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04092320 |
| Source dataset | uspto-grants-1978_05 |
| ORD ID | ord-4d9afe56171648ed98ab6d4844344cf7 |
| Source note | uspto-grants-1978_05 |