Hydrazinecarboxylic acid, ethyl ester → HCID 20326506, compound

HRID 372692Notes

Reaction equation

HRID 372692 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12](Cl)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)#[N:2].[C:16]([O:20][CH2:21][CH3:22])(=[O:19])[NH:17][NH2:18]>C(O)CCC>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12]([NH:18][NH:17][C:16]([O:20][CH2:21][CH3:22])=[O:19])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 64052563-Chloro-6-(4-cyanophenyl)pyridazine

Product 1

HCID 20326506HCID 20326506, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 0.40 g. of 6-(p-cyanophenyl)-3-chloropyridazine and 0.70 g. of 97% ethyl carbazate in 25 ml. of n-butanol is prepared. The solution is stirred and heated at reflux temperature for 4 hours. The reaction mixture is cooled to room temperature and the product precipitated from solution. The product is filtered, washed with n-butanol, water, dried and recrystallized from ethanol giving a crystalline material, m.p. 235° C.

Workup

  1. additionA mixture of 0.40 g
  2. temperatureheated
  3. temperatureat reflux temperature for 4 hours
  4. customthe product precipitated from solution
  5. filtrationThe product is filtered
  6. washwashed with n-butanol, water
  7. customdried
  8. customrecrystallized from ethanol giving a crystalline material, m.p. 235° C.

Sources & evidence

ORD record
ord-e19d2da95a6b4d57bc9b8267f64cd9f4
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

Loading…