反应详情

A mixture of 2.69 g. of 6-(p-bromophenyl)-3-chloropyridazine and 3.12 g. of ethyl carbazate in 50 ml. of n-butyl alcohol is prepared. This solution is stirred and heated at reflux temperature for 4 hours. The reaction mixture is cooled to room temperature and the solvent removed on a rotation evaporator. The residue is triturated with water and the resulting solid collected by filtration. The product is recrystallized from ethanol to give crystalline material, m.p. 190°-192° C.

1. additionA mixture of 2.69 g
2. temperatureheated
3. temperatureat reflux temperature for 4 hours
4. customthe solvent removed on a rotation evaporator
5. customThe residue is triturated with water
6. filtrationthe resulting solid collected by filtration
7. customThe product is recrystallized from ethanol
8. customto give crystalline material, m.p. 190°-192° C.