Hydrazinecarboxylic acid, ethyl ester → HCID 20326483, compound

HRID 372697Notes

Reaction equation

HRID 372697 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11](Cl)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:15]([O:19][CH2:20][CH3:21])(=[O:18])[NH:16][NH2:17]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:17][NH:16][C:15]([O:19][CH2:20][CH3:21])=[O:18])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 122575023-Chloro-6-(4-chlorophenyl)pyridazine

Product 1

HCID 20326483HCID 20326483, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 5.0 g. of 6-(p-chlorophenyl)-3-chloropyridazine and 6.86 g. of ethyl carbazate in 80 ml. of n-butyl alcohol is prepared. This solution is stirred and heated at reflux temperature for 4 hours. The reaction mixture is cooled in an ice bath and the resulting solid filtered, washed with n-butyl alcohol, water and dried. The product is recrystallized from ethanol to give crystalline material, m.p. 190°-192° C.

Workup

  1. additionA mixture of 5.0 g
  2. temperatureheated
  3. temperatureat reflux temperature for 4 hours
  4. temperatureThe reaction mixture is cooled in an ice bath
  5. filtrationthe resulting solid filtered
  6. washwashed with n-butyl alcohol, water
  7. customdried
  8. customThe product is recrystallized from ethanol
  9. customto give crystalline material, m.p. 190°-192° C.

Sources & evidence

ORD record
ord-644fa14b61e745019421f409c8ef9947
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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