反应详情

A mixture of 8.49 g. of 6-(p-bromophenyl)-5-methyl-3-chloropyridazine and 6.25 g. of ethyl carbazate in 100 ml. of n-butyl alcohol is prepared. This solution is stirred and heated at reflux temperature for 4 hours. The reaction mixture is cooled to room temperature and the solvent removed on a rotating evaporator. Water is added to the residue and the resulting solid filtered, washed with water, ether and dried. The product is recrystallized from ethanol to yield the product, m.p. 178°-179° C.

1. additionA mixture of 8.49 g
2. temperatureheated
3. temperatureat reflux temperature for 4 hours
4. customthe solvent removed on a rotating evaporator
5. additionWater is added to the residue
6. filtrationthe resulting solid filtered
7. washwashed with water, ether
8. customdried
9. customThe product is recrystallized from ethanol
10. customto yield the product, m.p. 178°-179° C.