反应详情

A 10.0 g. portion of 5-methyl-6-phenyl-3-chloropyridazine, 10.02 g. of ethyl carbazate and 150 ml. of butyl alcohol are stirred at reflux for 4 hours. The reaction mixture is concentrated free of butyl alcohol and the concentrate is placed in cold water containing a small amount of ethyl and scratched. The resulting solid is filtered, washed with water, recrystallized from a mixture of chloroform and petroleum ether and dried in vacuo giving a white solid, mp 143°-145° C.

1. temperatureat reflux for 4 hours
2. concentrationThe reaction mixture is concentrated free of butyl alcohol
3. filtrationThe resulting solid is filtered
4. washwashed with water
5. customrecrystallized from a mixture of chloroform and petroleum ether
6. customdried in vacuo
7. customgiving a white solid, mp 143°-145° C.