tert-Butyl carbazate → HCID 20326488, compound

HRID 372720Notes

Reaction equation

HRID 372720 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4](Cl)[N:5]=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1.[C:18]([O:22][C:23](=[O:26])[NH:24][NH2:25])([CH3:21])([CH3:20])[CH3:19]>C(O)CCC>[C:18]([O:22][C:23](=[O:26])[NH:24][NH:25][C:4]1[N:5]=[N:6][C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=2)=[C:2]([CH3:1])[CH:3]=1)([CH3:21])([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 70091tert-Butyl carbazateHCID 20398287HCID 20398287, compound

Product 1

HCID 20326488HCID 20326488, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 5.49 g. of 5-methyl-6-(m-nitrophenyl)-3-chloropyridazine and 8.71 g. of t-butylcarbazate in 100 ml. of butanol is heated at reflux for 3 hours and then allowed to cool to room temperature overnight. The butanol is removed on a rotating evaporator leaving a heavy liquid residue. The final product is obtained after crystallization from a minimum amount of methanol on standing, washing with methanol, water and drying, m.p. 160°-162° C.

Workup

  1. additionA mixture of 5.49 g
  2. temperatureat reflux for 3 hours
  3. customThe butanol is removed on a rotating evaporator
  4. customleaving a heavy liquid residue

Sources & evidence

ORD record
ord-5ac0695ca5fd44d593ff4864f1d5a3d6
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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