Hydrazinecarboxylic acid, ethyl ester → Ethyl 3-(6-phenyl-3-pyridazinyl)carbazate

HRID 372724Notes

Reaction equation

HRID 372724 reaction equation
[C:1]1([C:7]2[N:12]=[N:11][C:10](Cl)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:14]([O:18][CH2:19][CH3:20])(=[O:17])[NH:15][NH2:16]>C(O)CCC>[C:1]1([C:7]2[N:12]=[N:11][C:10]([NH:16][NH:15][C:14]([O:18][CH2:19][CH3:20])=[O:17])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 885153-Chloro-6-phenylpyridazine

Product 1

HCID 20326484Ethyl 3-(6-phenyl-3-pyridazinyl)carbazate

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 15.0 g. of 6-phenyl-3-chloropyridazine, 16.3 g. of ethyl carbazate, and 250 ml. of n-butanol is refluxed for 3 hours. The solvent is removed under vacuum and the residue triturated with cold water. Filtration gives 18.6 g. of cream colored crystals. Recrystallization gives white crystals, m.p. 158°-160° C.

Workup

  1. additionA mixture of 15.0 g
  2. customThe solvent is removed under vacuum
  3. customthe residue triturated with cold water
  4. filtrationFiltration
  5. customgives 18.6 g
  6. customRecrystallization
  7. customgives white crystals, m.p. 158°-160° C.

Sources & evidence

ORD record
ord-f95a9d5aba3746688876fecc16b15b16
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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