Hydrochloric Acid → HCID 20326489, compound

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Reaction Steps

A solution of 2.87 g. of ethyl 3-[6-(m-aminophenyl)-5-methyl-3-pyridazinyl]carbazate, 80 ml. of water, 10 ml. of concentrated hydrochloric acid is stirred at 0° and a solution of 0.76 g. of sodium nitrite in 10 ml. of water added dropwise over 10 minutes. After stirring for 15 minutes, the cold solution is added dropwise to a cold solution of 2.5 g. of cuprous cyanide, 2.27 g. of potassium cyanide, 50 ml. of water and 35 ml. of toluene. After stirring at 0° for 1 hour and at room temperature overnight, the mixture is filtered and the solid washed with water to give 4.3 g. of gray crystals. Purification gives product as crystals, m.p. 189°-190° C.

Provenance & Evidence