Methyl carbazate → HCID 20326512, compound

HRID 372727Notes

Reaction equation

HRID 372727 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12](Cl)=[CH:11][C:10]=2[CH3:16])=[CH:5][CH:4]=1)#[N:2].[C:17]([O:21][CH3:22])(=[O:20])[NH:18][NH2:19]>C(O)CCC>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[N:13][C:12]([NH:19][NH:18][C:17]([O:21][CH3:22])=[O:20])=[CH:11][C:10]=2[CH3:16])=[CH:5][CH:4]=1)#[N:2]

Participants

4

Reactant 2

HCID 80519Methyl carbazateHCID 13424594HCID 13424594, compound

Product 1

HCID 20326512HCID 20326512, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A mixture of 18.0 g. of 6-(p-cyanophenyl)-5-methyl-3-chloropyridazine, 13.3 g. of methyl carbazate and 200 ml. of n-butanol is refluxed for 3 hours. The solvent is removed to give an oil which crystallizes on addition of water to give 11.9 g. of product. Recrystallization from methanol-ether gives white crystals, m.p. 191°-192° C.

Workup

  1. additionA mixture of 18.0 g
  2. customThe solvent is removed
  3. customto give an oil which
  4. customcrystallizes on addition of water
  5. customto give 11.9 g
  6. customRecrystallization from methanol-ether
  7. customgives white crystals, m.p. 191°-192° C.

Sources & evidence

ORD record
ord-fd846892cac444e9a764e44a75eedcec
Source dataset
uspto-grants-1978_05
Patent number
US04092311

Reaction notes

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