Dimethyl Sulfate → HCID 20326563, compound

HRID 372737Notes

Reaction equation

HRID 372737 reaction equation
[C:1]1([S:7]([C:9]2[CH:10]=[CH:11][C:12](=[S:15])[NH:13][CH:14]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].S(OC)(O[CH3:22])(=O)=O>>[CH3:22][S:15][C:12]1[CH:11]=[CH:10][C:9]([S:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[O:8])=[CH:14][N:13]=1

Participants

4

Reactant 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 20326566HCID 20326566, compound

Product 1

HCID 20326563HCID 20326563, compound

Procedure

A solution of 5-(phenylsulfinyl)pyridine-2-thione (2.21 g., .01 moles) in 25 ml. of 2.5N sodium hydroxide is treated with 1.6 g. of dimethyl sulfate. After stirring at room temperature for 3 hours, the reaction mixture is extracted with methylene chloride. The extracts are washed with water, dried and evaporated in vacuo to yield 2-(methylthio)-5-(phenylsulfinyl)pyridine.

Workup

  1. extractionthe reaction mixture is extracted with methylene chloride
  2. washThe extracts are washed with water
  3. customdried
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-49337614c319434d86c34ce9fd7bfaf2
Source dataset
uspto-grants-1978_05
Patent number
US04092321

Reaction notes

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