Sodium Methoxide → 2-Methoxy-5-phenylsulfinylpyridine

HRID 372740Notes

Reaction equation

HRID 372740 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][N:3]=1.[CH3:16][O-:17].[Na+]>CO>[CH3:16][O:17][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 203265642-Bromo-5-phenylsulfinylpyridine

Product 1

HCID 203265602-Methoxy-5-phenylsulfinylpyridine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-bromo-5-phenylsulfinylpyridine (2.82 g., 0.01 mole) and 0.50 g. of sodium methoxide is heated in 50 ml. of refluxing methanol for 5 hours. The reaction mixture is evaporated in vacuo, and the residue is diluted with water. The solids are collected by filtration, washed with water and dried to yield 2-methoxy-5-phenylsulfinylpyridine.

Workup

  1. customThe reaction mixture is evaporated in vacuo
  2. additionthe residue is diluted with water
  3. filtrationThe solids are collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-08450c8075fc4dc7bf677910a004504e
Source dataset
uspto-grants-1978_05
Patent number
US04092321

Reaction notes

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