関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Hexamethylphosphoramide | HCID 12679 | — |
| 反応物 | methyl N-(2-chloroacetyl)carbamate | HCID 518783 | — |
| 反応物 | 2-Chloro-5-(phenylsulfinyl)pyridine | HCID 20326561 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2-(Methoxycarbonylamino)-5-(phenylsulfinyl) imidazo [1,2-a] pyridine | HCID 53633625 | — |
反応手順
A solution of 2-chloro-5-(phenylsulfinyl)pyridine (2.37 g., .01 mole) in 10 ml. of hexamethylphosphoramide is treated with 2.2 g. of methylchloroacetylcarbamate. The solution is warmed to 50° C for 1 hour, cooled, combined with 5 ml. of methanol and saturated with anhydrous ammonia. The mixture is warmed at 100° C for 3 hours. After cooling, the reaction mixture is diluted with 5 volumes of ether and the crude product is collected by filtration. Recrystallization from hot methanol yields 2-(methoxycarbonylamino)-5-(phenylsulfinyl) imidazo [1,2-a] pyridine, m.p. 249°-251° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04092321 |
|---|
| 出典データセット | uspto-grants-1978_05 |
|---|
| ORD ID | ord-db7c1e1e7d624561a632855206c1aa05 |
|---|
| 出典メモ | uspto-grants-1978_05 |
|---|
