反应详情

温度

95 °C

-- A mixture of 35.0 g (0.5 mole) of propiolic acid, 97 g (0.5 mole) of 3-mercaptoindole and 500 ml of 1N NaOH solution is stirred for 1 hour at 95° C. The solution is cooled and the precipitated solid washed with water and discarded. The filtrate is acidified with 4N HCl and the gummy precipitate extracted with ether. The ether is dried and evaporated and the residue recrystallized from 250 ml of acetonitrile to give 88 g of product, mp 172°-173° C.

1. temperatureThe solution is cooled
2. washthe precipitated solid washed with water
3. extractionthe gummy precipitate extracted with ether
4. dry with materialThe ether is dried
5. customevaporated
6. customthe residue recrystallized from 250 ml of acetonitrile