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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 372771Generated: October 25, 2026

Hydrochloric Acid → Glycyl-glycine benzyl ester hydrochloride

https://huagongshe.com/reaction/372771

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantBenzyl (tert-butoxycarbonyl)glycylglycinateHCID 3244524—
Solvent1,4-DioxaneHCID 31275—
ProductGlycyl-glycine benzyl ester hydrochlorideHCID 13996146—

Reaction Steps

10.3 Parts N-t-butoxycarbonylglycylglycine benzyl ester is dissolved in 200 parts dioxane and treated with a 10 fold excess of 2 N hydrochloric acid in dioxane for 10 minutes. Removal of the solvent under reduced pressure affords pure glycylglycine benzyl ester hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04092304
Source datasetuspto-grants-1978_05
ORD IDord-649622d36011435d853bf41132b09046
Source noteuspto-grants-1978_05