HCID 53691605, compound → HCID 54393979, compound

HRID 372779Notes

Reaction equation

HRID 372779 reaction equation
ClC1C(OC(=O)[C@H:10]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]([CH3:29])([CH3:28])[CH3:27])=[CH:22][CH:21]=2)[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=C(Cl)C(Cl)=C(Cl)C=1Cl.[CH2:35]([O:42][C:43](=[O:71])[C@H:44]([CH2:67][CH2:68][S:69][CH3:70])[NH:45][C:46](=[O:66])[C@H](CC1C2C(=CC=CC=2)NC=1)NC(OC(C)(C)C)=O)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[CH2:35]([O:42][C:43](=[O:71])[C@H:44]([CH2:67][CH2:68][S:69][CH3:70])[NH:45][C:46](=[O:66])[C@H:10]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]([CH3:29])([CH3:28])[CH3:27])=[CH:24][CH:25]=1)[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

Participants

3

Reactant 2

HCID 53691605HCID 53691605, compoundHCID 53790063HCID 53790063, compound

Product 1

HCID 54393979HCID 54393979, compound

Procedure

When an equivalent quantity of N-t-butoxycarbonyl-p-t-butyl-L-phenylalanine pentachlorophenyl ester is substituted for the N-t-butoxycarbonyl-L-tryptophan 2,4,5-trichlorophenyl ester of Example 5 and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-p-t-butyl-L-phenylalanyl-L-methionine benzyl ester.

Sources & evidence

ORD record
ord-2157a97b03e941788bd6d85e7973ca3f
Source dataset
uspto-grants-1978_05
Patent number
US04092304

Reaction notes

Loading…