HCID 54293522, compound → HCID 53851109, compound

HRID 372782Notes

Reaction equation

HRID 372782 reaction equation
Cl.[CH2:2]([O:9][C:10](=[O:27])[C@H:11]([CH2:23][CH2:24][S:25][CH3:26])[NH:12][C:13](=[O:22])[C@H:14]([CH2:16][C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)[NH2:15])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(OC(=O)[C@H](CCSC)NC(=O)[C@H](CC1C2C(=CC=CC=2)NC=1)N[C:42](=[O:68])[CH2:43][NH:44][C:45](=[O:67])[CH2:46][NH:47][C:48](=[O:66])[C@H:49]([CH2:58][C:59]1[CH:64]=[CH:63][C:62]([OH:65])=[CH:61][CH:60]=1)[NH:50][C:51]([O:53][C:54]([CH3:57])([CH3:56])[CH3:55])=[O:52])C1C=CC=CC=1>>[CH2:2]([O:9][C:10](=[O:27])[C@H:11]([CH2:23][CH2:24][S:25][CH3:26])[NH:12][C:13](=[O:22])[C@H:14]([CH2:16][C:17]1[S:18][CH:19]=[CH:20][CH:21]=1)[NH:15][C:42](=[O:68])[CH2:43][NH:44][C:45](=[O:67])[CH2:46][NH:47][C:48](=[O:66])[C@H:49]([CH2:58][C:59]1[CH:64]=[CH:63][C:62]([OH:65])=[CH:61][CH:60]=1)[NH:50][C:51]([O:53][C:54]([CH3:56])([CH3:57])[CH3:55])=[O:52])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 54293522HCID 54293522, compoundHCID 70620190HCID 70620190, compound

Product 1

HCID 53851109HCID 53851109, compound

Procedure

When an equivalent quantity of β-(2-thienyl)-L-alanyl-L-methionine benzyl ester hydrochloride is substituted for the L-tryptophyl-L-methionine benzyl ester hydrochloride of Example 7 and the procedure detailed therein substantially repeated, there is obtained N-t-butoxycarbonyl-L-tyrosylglycylglycyl β-(2-thienyl)-L-alanyl-L-methionine benzyl ester.

Sources & evidence

ORD record
ord-92dacedf7bf141d5bcef29bb60f3923d
Source dataset
uspto-grants-1978_05
Patent number
US04092304

Reaction notes

Loading…