反应详情

35.5 g of β-hydroxy-β,β-diphenyl-propionitrile are added portionwise to the stirred suspension of 12.9 g of lithium aluminum hydride in 800 ml of diethyl ether while cooling with an ice bath. After stirring for 15 hours at room temperature and 2 hours at the boil, it is cooled again and 12.9 ml of water, 12.9 ml of 15% aqueous sodium hydroxide and 38.7 ml of water are added in this order. The mixture is filtered, the residue washed 3 times with 150 ml of methylene chloride, the filtrate dried, evaporated and the residue recrystallized from ethanol, to yield the 3-hydroxy-3,3-diphenyl-propylamine melting at 134°-136°.

1. temperaturewhile cooling with an ice bath
2. temperatureis cooled again
3. filtrationThe mixture is filtered
4. washthe residue washed 3 times with 150 ml of methylene chloride
5. customthe filtrate dried
6. customevaporated
7. customthe residue recrystallized from ethanol