Water → HCID 20326630, compound

HRID 372795Notes

Reaction equation

HRID 372795 reaction equation
[C:1]1([C:7]2([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13][CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:20]1[O:22][CH2:21]1.O>CO>[OH:22][CH2:21][CH2:20][N:10]1[CH2:9][CH2:8][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[O:13][CH2:12][CH2:11]1

Participants

5

Reactant 3

HCID 962WaterHCID 6354Ethylene OxideHCID 203266297,7-Diphenyl-1,4-oxazepane

Product 1

HCID 20326630HCID 20326630, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of 6.5 g of 7,7-diphenyl-hexahydro-1,4-oxazepine, 1.2 g of ethylene oxide, 0.5 ml of water and 20 ml of methanol is stirred at 40°-45° for 4 hours and at 50° for 21/2 hours. It is cooled, the precipitate formed, filtered off and recrystallized from benzene-hexane, to yield the 4-(2-hydroxyethyl)-7,7-diphenyl-hexahydro-1,4-oxazepine melting at 122°-123° (its hydrochloride melts at 190°-192°).

Workup

  1. temperatureIt is cooled
  2. customthe precipitate formed
  3. filtrationfiltered off
  4. customrecrystallized from benzene-hexane

Sources & evidence

ORD record
ord-696f640422c847e5bf729029cf5eea8f
Source dataset
uspto-grants-1978_05
Patent number
US04092330

Reaction notes

Loading…