Phosphonoacetic Acid → Methylacetylphosphonate

HRID 372824Notes

Reaction equation

HRID 372824 reaction equation
[P:1]([CH2:5][C:6]([OH:8])=[O:7])([OH:4])([OH:3])=[O:2].[CH3:9]O>>[P:1]([CH2:5][C:6]([O:8][CH3:9])=[O:7])([OH:4])([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 546Phosphonoacetic AcidHCID 887Methanol

Product 1

HCID 170449Methylacetylphosphonate

Procedure

Phosphonoacetic acid, 5 g., was dissolved in 25 ml. methyl alcohol. Dry hydrogen chloride was bubbled through the solution for 30 minutes at O° C. The solution was refluxed for 4 hours. Evaporation of the solvent left an oil which was dried in vacuo over P2O5 and NaOH.

Workup

  1. dissolution, was dissolved in 25 ml
  2. customDry hydrogen chloride was bubbled through the solution for 30 minutes at O° C
  3. temperatureThe solution was refluxed for 4 hours
  4. customEvaporation of the solvent
  5. waitleft an oil which
  6. dry with materialwas dried in vacuo over P2O5 and NaOH

Sources & evidence

ORD record
ord-e713fe8e17ed41778c36d3a33e7ed9e7
Source dataset
uspto-grants-1978_05
Patent number
US04092412

Reaction notes

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