3-Chloropropionyl chloride → HCID 10517794, compound

Participants

Reaction Steps

17.2 g of 2 -methoxy 4-nitro 5 -chloroaniline dissolved in 150 ml benzene are added with 11.1g of β chloropropionyl chloride dissolved in 40 ml benzene and 2 ml pyridine. The reaction mixture is kept under stirring at room temperature of 2 hours then diluted with 250 ml water. The benzenic phase is separated while the aqueous phase is extracted twice with benzene. The benzenic solutions are united, washed with 2N hydrochloric acid then with water, dried on sodium sulphate, filtered and evaporated to dryness. The dry residue is recrystallised from isopropyl ether and 21.1g of 1(β chloropropionylamino) 2-methoxy 4-nitro 5 -chlorobenzene are recovered (yield 40-50%). It melts at 101°-110° (dec).

Provenance & Evidence