N-[2-(7-hydroxy-1-naphthyl)ethyl]cyclopropanecarboxamide → N-{2-[7-(cyclohexen-3-yl)oxy-1-naphthyl]ethyl}cyclobutanecarboxamide
Reaction equation
O[C:2]1[CH:11]=[C:10]2[C:5](C=CC=C2CCNC(C2CC2)=O)=[CH:4][CH:3]=1.[OH:20][C:21]1[CH:30]=[C:29]2[C:24]([CH:25]=[CH:26][CH:27]=[C:28]2[CH2:31][CH2:32][NH:33][C:34]([CH:36]2[CH2:39][CH2:38][CH2:37]2)=[O:35])=[CH:23][CH:22]=1>>[CH:2]1[CH2:11][CH2:10][CH2:5][CH:4]([O:20][C:21]2[CH:30]=[C:29]3[C:24]([CH:25]=[CH:26][CH:27]=[C:28]3[CH2:31][CH2:32][NH:33][C:34]([CH:36]3[CH2:39][CH2:38][CH2:37]3)=[O:35])=[CH:23][CH:22]=2)[CH:3]=1Participants
3
Procedure
Using the procedure described in Example 25, but replacing the compound obtained in Example 24 by the compound obtained in Example 41, N-{2-[7-(cyclohexen-3-yl)oxy-1-naphthyl]ethyl}cyclobutanecarboxamide is obtained.
Sources & evidence
- ORD record
- ord-14a4e89ab735446ead08dec3ad555b74
- Source dataset
- uspto-grants-1995_05
- Patent number
- US05420158
Reaction notes
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