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HRID372893

反应详情

EQUATION

反应方程式

HRID 372893 的结构方程式

REACTANTS

反应物

4
结构：Cc1ccc(S(=O)(=O)N(C)N=O)cc1
HCID6628

N-Methyl-N-nitrosotoluene-4-sulphonamide

C8H10N2O3S

结构：C=[N+]=[N-]
HCID9550

Diazomethane

CH2N2

2 次

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：CCCCCC(CCCC(CCCCCCC(=O)OCC)C(=O)Cl)OC(C)=O
HCID20322197

Ethyl 12-(acetyloxy)-8-(chlorocarbonyl)heptadecanoate

C22H39ClO5

PRODUCTS

生成物

1
结构：CCCCCC(CCCC(CCCCCCC(=O)OCC)C(=O)C=[N+]=[N-])OC(C)=O
HCID54204114

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCOCC
溶剂HCID3283

Diethyl Ether

C4H10O

2 次

结构：CCOCCOCCO.O
溶剂HCID131711019

未命名化合物

PROCEDURE

实验过程

Diazomethane (6 g., 0.143 mole) is generated via dropwise addition of a solution of Diazald® (43 g.) in ether (400 ml.) over 45 minutes to a warm (65%), stirred solution of potassium hydroxide (12 g., 0.214 mole) in carbitol-water (7:2, 90 ml.). The resulting yellow, ethereal diazomethane distillate is cooled to 0° and treated with a solution of ethyl 8-chlorocarbonyl-12-acetoxyheptadecanoate (8.1 g., 0.02 mole) (Example 7, Step D), in ether (40 ml.) added over a period of 15 minutes.

WORKUP

后处理

  1. temperaturea warm (65%)
  2. additionadded over a period of 15 minutes