4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine → HCID 54562017, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5.4 g of 2-(i-propoxycarbonyl) benzenesulfonyl isocyanate (20 mmol) in 5.4 g of 1,2-dichloroethane is added dropwise over the course of 5 min to a solution of 3.9 g of 2-amino-4-methoxy-6-trifluoromethyl-1,3, 5-triazine (20 mmol) in 150 ml of 1,2-dichloroethane at 25° C. The mixture is stirred at 25° C. for 16 h and then at 50° C. for 2 h. After removal of the volatiles under waterpump vacuum at 60° C., the residue is stirred with a mixture of ethanol and pentane, when crystallization occurs. The product is filtered off with suction and dried at 50° C. under waterpump vacuum. 6.1 g of the title compound (13 mmol; 66% of theory) are isolated with melting point 182°-185° C.

Provenance & Evidence